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Possible contributing factors may include aging itself, medications, and chronic illness. Further research in this area is clearly warranted. Genetic Studies Patients with hypergonadotropic hypogonadism and impaired pubertal development associated with small, firm testes and often with gynecomastia are likely to have Klinefelter’s syndrome or a variant. Classically, a buccal smear was done to establish the diagnosis by revealing Barr bodies. We currently recommend genetic karyotype testing to confirm the diagnosis in a patient with these findings at initial assessment.

 

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